Bao-Liang Song Selected Research

Cardiovascular Diseases (Cardiovascular Disease)

1/2023	New Loss-of-Function Mutations in PCSK9 Reduce Plasma LDL Cholesterol.
6/2022	Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol.
1/2022	Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and Protects Against Atherosclerosis.
1/2020	Mechanisms and regulation of cholesterol homeostasis.
1/2020	Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase.
1/2020	In Vivo AAV-CRISPR/Cas9-Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia.
12/2019	IDOL G51S Variant Is Associated With High Blood Cholesterol and Increases Low-Density Lipoprotein Receptor Degradation.
11/2019	Regulation of glucose and lipid metabolism in health and disease.
12/2018	Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol.
1/2018	A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption.

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Bao-Liang Song Research Topics

Disease

12	Cardiovascular Diseases (Cardiovascular Disease) 01/2023 - 01/2014
9	Neoplasms (Cancer) 10/2023 - 12/2013
7	Atherosclerosis 11/2022 - 06/2009
6	Insulin Resistance 11/2022 - 01/2011
5	Atherosclerotic Plaque (Atheroma) 01/2022 - 01/2011
4	Hepatocellular Carcinoma (Hepatoma) 12/2020 - 03/2006
3	Obesity 11/2022 - 01/2011
3	Non-alcoholic Fatty Liver Disease 11/2022 - 01/2020
3	Hyperlipidemias (Hyperlipidemia) 01/2021 - 01/2011
3	Hypercholesterolemia 01/2020 - 01/2014
2	Peroxisomal Disorders (Peroxisomal Disorder) 01/2023 - 04/2015
2	Metabolic Diseases (Metabolic Disease) 12/2020 - 08/2012
2	Fatty Liver 12/2020 - 11/2019
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 07/2015
2	Melanoma (Melanoma, Malignant) 01/2019 - 03/2016
2	Inflammation (Inflammations) 11/2018 - 01/2017
1	Basal Cell Carcinoma (Rodent Ulcer) 02/2024
1	Medulloblastoma 02/2024
1	Lung Injury 10/2023
1	Hypokinesia (Bradykinesia) 10/2023
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2023
1	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 01/2023
1	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 01/2023
1	Body Weight (Weight, Body) 12/2020
1	Dyslipidemias (Dyslipidemia) 01/2020
1	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2020
1	Weight Gain 01/2019
1	of Schnyder Crystalline Corneal Dystrophy 01/2019
1	Eye Diseases (Eye Disease) 01/2019
1	Carcinogenesis 04/2017
1	Cardiomegaly (Heart Hypertrophy) 10/2016
1	Ventricular Tachycardia 10/2016
1	Heart Failure 10/2016
1	Virus Diseases (Viral Diseases) 07/2015
1	Infections 07/2015
1	Weight Loss (Weight Reduction) 02/2015
1	Carcinoma (Carcinomatosis) 02/2015

Drug/Important Bio-Agent (IBA)

20	CholesterolIBA 10/2023 - 12/2013
6	LDL CholesterolIBA 01/2023 - 10/2016
6	LipidsIBA 12/2020 - 01/2011
4	oxidized low density lipoproteinIBA 01/2023 - 10/2016
3	Sterol Regulatory Element Binding ProteinsIBA 11/2022 - 02/2015
3	Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA 06/2022 - 12/2018
3	EnzymesIBA 06/2022 - 07/2015
2	LDL Receptors (LDL Receptor)IBA 01/2022 - 01/2020
2	Apolipoproteins E (ApoE)IBA 01/2022 - 10/2019
2	betulinIBA 01/2021 - 01/2011
2	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 01/2021 - 01/2017
2	Sterol O-AcyltransferaseIBA 12/2020 - 03/2006
2	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 12/2018
2	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2014
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2020 - 12/2018
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017 - 06/2009
2	OxysterolsIBA 07/2015 - 12/2013
1	HhAntag691IBA 02/2024
1	Chimeric Antigen ReceptorsIBA 10/2023
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2023
1	tazemetostatIBA 01/2023
1	MethyltransferasesIBA 01/2023
1	Insulin (Novolin)FDA Link 11/2022
1	Islet Amyloid PolypeptideIBA 11/2022
1	PrekallikreinIBA 01/2022
1	ApolipoproteinsIBA 01/2022
1	Mechanistic Target of Rapamycin Complex 1IBA 12/2020
1	Apolipoproteins B (ApoB)IBA 01/2020
1	Coenzyme A (CoA)IBA 01/2020
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2020
1	Triglycerides (Triacylglycerol)IBA 01/2020
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2020
1	CRISPR-Cas Systems Guide RNAIBA 01/2020
1	Atorvastatin (Lipitor)FDA Link 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 11/2019
1	Glycoproteins (Glycoprotein)IBA 01/2019
1	Neutralizing AntibodiesIBA 01/2019
1	IgA receptor (protein B)IBA 01/2019
1	CytokinesIBA 01/2017
1	InterleukinsIBA 01/2017
1	GlycogenIBA 10/2016
1	avasimibeIBA 03/2016
1	Poly IIBA 07/2015
1	cholesterol 25-hydroxylaseIBA 07/2015
1	Antiviral Agents (Antivirals)IBA 07/2015
1	Transcription Factors (Transcription Factor)IBA 07/2015
1	InterferonsIBA 07/2015
1	LaxativesIBA 02/2015
1	chrysophanic acidIBA 02/2015
1	Messenger RNA (mRNA)IBA 02/2015
1	fibroblast growth factor 21IBA 08/2012
1	Cholesterol Esters (Cholesteryl Esters)IBA 06/2009
1	Biomarkers (Surrogate Marker)IBA 03/2006

Therapy/Procedure

2	Therapeutics 01/2020 - 12/2018
1	Heart Transplantation (Grafting, Heart) 10/2016
1	Immunotherapy 03/2016